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KMID : 0363219940320020337
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Korean Journal of Dermatology
1994 Volume.32 No. 2 p.337 ~ p.341
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Therapeutic Effectivity of Intralesional Injection of 5-fluorouracil to Basal External Genitalia
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Abstract
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Basal cell carcinomas(BCCs) are usually treated with ablative procedures, but a nonsurgical treatment would conserve tissue and obtain a better cosmetic out come as well as treat patients who refuse surgery of those who are not good surgical
candidates.
Because of inadequate drug penetration, low cure rates, high recurrence rates, and adverse reactions, such as contact dermatitis, topical 5-fluorouracil(5-FU) is unsuitable to treat nodular BCCs. But intralesional 5-FU has been reported to be
effective
for nodular BCCs.
The efficacy and safety of intralesional injection of 5-FU have been evaluated for treatment of BCCs. The results revealed that intralesional injection of 5-FU seems to be effective in the treatment of various premalignant and malignant skin
lesions as
well as BCCs without side effects. (Kor J Dermatol 1994 ; 32(2) : 337~241)
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